Therapy Promotes Venous Thromboembolism Through The...

Antiangiogeneic therapy promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma Ni Chen1*, Meiping Ren1*, Rong Li1, Xin Deng1, Yongjie Li1, Kai Yan1, Lamei Xiao1 , Yan Yang1, Liqun Wang 1, Mao Luo 1, William P. Fay 2, Jianbo Wu1,2 1Drug Discovery Research Center, Luzhou, Sichuan, People s Republic of China; 2Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO, USA Corresponding author: Jianbo Wu, Division of Cardiovascular Medicine, University of Missouri, 5 Hospital Drive, CE344–DC095.00, Columbia, Missouri 65212. Email: wuji@missouri.edu, Phone: 573-884-4040, Fax: (573) 884-7743. * These authors contributed equally to this work. Key Points †¢ Bevacizumab promotes VTE through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma †¢ Treatment with a PAI-1 inhibitor reduces bevacizumab-induced VTE. Abstract Thromboembolism is a major source of morbidity and mortality in patients with cancer. An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism of VTE initiation remains elusive. In this study, we examined the effect of bevacizumab, a humanized monoclonal antibody against VEGF-A, on either an inferior vena cava stenosis or saphenous vein model in a xenograft mouse model. We found that treatment with bevacizumab accelerated

Spooky Scenes from Classic Literature

If you need inspiration for this years Halloween reading selections, look no further than these eerie teases from classic literature.   â€Å"A Rose for Emily† (1930) by William Faulkner â€Å"Already we knew that there was one room in that region above stairs which no one had seen in forty years, and which would have to be forced. They waited until Miss Emily was decently in the ground before they opened it. The violence of breaking down the door seemed to fill this room with pervading dust. A thin, acrid pall as of the tomb seemed to lie everywhere upon this room decked and furnished as for a bridal: upon the valance curtains of faded rose color, upon the rose-shaded lights, upon the dressing table, upon the delicate array of crystal and the mans toilet things backed with tarnished silver, silver so tarnished that the monogram was obscured. Among them lay a collar and tie, as if they had just been removed, which, lifted, left upon the surface a pale crescent in the dust. Upon a chair hung the suit, carefully folded; beneath it the two mute shoes and the discarded socks.† â€Å"The Tell-Tale Heart† (1843) by Edgar Allan Poe â€Å"It is impossible to say how first the idea entered my brain; but once conceived, it haunted me day and night. Object there was none. Passion there was none. I loved the old man. He had never wronged me. He had never given me insult. For his gold I had no desire. I think it was his eye! yes, it was this! He had the eye of a vulture --a pale blue eye, with a film over it. Whenever it fell upon me, my blood ran cold; and so by degrees --very gradually --I made up my mind to take the life of the old man, and thus rid myself of the eye forever.† The Haunting of Hill House (1959) by Shirley Jackson â€Å"No live organism can continue for long to exist sanely under conditions of absolute reality; even larks and katydids are supposed, by some, to dream. Hill House, not sane, stood by itself against its hills, holding darkness within; it had stood so for eighty years and might stand for eighty more. Within, walls continued upright, bricks met neatly, floors were firm, and doors were sensibly shut; silence lay steadily against the wood and stone of Hill House, and whatever walked there, walked alone.† The Legend of Sleepy Hollow (1820) by Washington Irving On mounting a rising ground, which brought the figure of his fellow-traveller in relief against the sky, gigantic in height, and muffled in a cloak, Ichabod was horror-struck on perceiving that he was headless!--but his horror was still more increased on observing that the head, which should have rested on his shoulders, was carried before him on the pommel of his saddle! (1898) by Henry James â€Å"It was as if, while I took in – what I did take in – all the rest of the scene had been stricken with death. I can hear again, as I write, the intense hush in which the sounds of evening dropped. The rooks stopped cawing in the golden sky, and the friendly hour lost, for the minute, all its voice. But there was no other change in nature, unless indeed it were a change that I saw with a stranger sharpness. The gold was still in the sky, the clearness in the air, and the man who looked at me over the battlements was as definite as a picture in a frame. Thats how I thought, with extraordinary quickness, of each person that he might have been and that he was not. We were confronted across our distance quite long enough for me to ask myself with intensity who then he was and to feel, as an effect of my inability to say, a wonder that in a few instants more became intense.† (1838) by Edgar Allan Poe â€Å"A sullen darkness now hovered above us- but from out the milky depths of the ocean a luminous glare arose, and stole up along the bulwarks of the boat. We were nearly overwhelmed by the white ashy shower which settled upon us and upon the canoe, but melted into the water as it fell. The summit of the cataract was utterly lost in the dimness and the distance. Yet we were evidently approaching it with a hideous velocity. At intervals there were visible in it wide, yawning, but momentary rents, and from out these rents, within which was a chaos of flitting and indistinct images, there came rushing and mighty, but soundless winds, tearing up the enkindled ocean in their course.†

The Discovery Of African Slavery - 1984 Words

Slavery has been a controversial topic especially in the U.S due to the attachment that the country has on this matter. Over the cause of history, different group of people have been associate with this practice where by in most cases the weak communities are the one that are subjected to the slavery. The early centauries were particularly characterized with kingdoms attacking other smaller kingdoms and capturing prisoners who they later used as slaves in their own kingdoms (Blassingame 1979). The bible also have stories about slavery which proves that it was quite a normal practice for many years. Perhaps the most documented and exploited tale under this category is slavery in America which last for a number of centauries and so millions†¦show more content†¦Factors that lead to the spread of slavery Developmental factors played an important role in the spread of slavery since more and more people were shipped to the U.S in order to provide free labor. This meant that the country could expand its economic on the expense of the labor provided by the black slaves. As a result, slave grew tremendously in the U.S especially in the south since the farmers in that area need cheap labor to work on their farms. Other ideologies that lead to the spread of slavery include the belief that Africans were inferior to white. The white people therefore viewed slavery as a way for them to liberate the black people. Many conservative white people shared the view that by offering black people odd job and a chance to live among white people they could also be civilized as them (Blassingame 1979). Significance of slavery in the U.S Slavery spread immensely in the U.S than it did in Europe since America had a bigger market for slaves and Europe did not require cheap labor since it already had indigenous white labor. Slavery was therefore very significant in the U.S since not only did America have the highest number of slave supplies, slavery also lead to the Civil war which was the bloodiest was ever fought in the U.S. the civil war was triggered by the drift between the north region and

Alex Wen. Ms. Mendola. Ap Language And Composition. 9 January

Alex Wen Ms. Mendola AP Language and Composition 9 January 2017 The Battle of Transgender Equality Everyone is given a gender the moment they are born. At birth they are either one of two genders: masculine or feminine. This gender everyone is assigned affects many of our day to day actions and our looks. However some people may evolve differently as they grow up and may not fit the rigid boundaries set for the sex they were assigned at birth. In recent years there has been a boom in a third considered gender: the transgender population. However with the boom comes the argument of to what extent should transgender people be protected by the government. Throughout the existence of transgender people, the rights of transgenders have been†¦show more content†¦This is in direct correlation with the increased probability of mental illnesses in the transgender population. Traditional views certainly do not help as many transgender citizens are told they are â€Å"sick† because of their difference with many religious and personal beliefs. A study from Boston published ear lier this year in the Journal of Adolescent Health, reported that transsexual youth had two to three times increased risk of psychiatric disorders, including depression, anxiety disorder, suicidal ideation, suicide attempt, self-harm without lethal intent, and both inpatient and outpatient mental health treatment. These statistics show the clear consequences of mental health transgenders are facing if transgender rights continues to be unregulated. It is essential that the federal government steps in to take action in order to make sure things do not continue on this downwards path. Some citizens support the idea of laws and rules being passed in support of transgenders rights, but they believe that the federal government does not need to be involved. They believe that schools, institutions, and the workplace can regulate themselves. Although America is showing progress towards transgender equality, there are still many who refuse to acknowledge

Report on Mental Health Nursing Samples †MyAssignmenthelp.com

Question: Discuss about the Report on Mental Health Nursing. Answer: The Mental Health Services is a report that was published on the Australian website to provide a glimpse of the annual report of the main statistics as well as related information regarding mental health services. The report incorporates updates made to the Australian platform over the duration of one year to November 2014. According to the report, the common mental disorders or illnesses are drug or substance abuse, anxiety and depression while those less common are bipolar and schizoaffective disorders as well as schizophrenia. Statistically, the report shows that about 46% of Australians from teenagers to the elderly experienced some kind of mental illness at some point in their life time, and about 20% experienced a common mental illness in the previous one year, that is 2006. Of such, anxiety disorders were very common affecting over 14% of the Australian population, followed by affective disorder with 6.2 % and lastly were substance use disorder with about 5.0%. Also, the repor t shows that the occurrence of these disorders was common in females compared to their male counterparts in all ages. Regarding more serious mental illnesses like psychotic disorders, a survey done in 2010 showed that 0.45% of the people living with this condition sought treatment annually from mental health services in the public sector. The impact of mental illness from the report indicates that up to 3% of Australians have serious mental disorders while 4 to 6% have moderate disorders and further 10 to 12% have mild disorders. Ideally, in 2011, the author states that mental illness was the primary cause of over 750 deaths. Statistics show that mental plus behavioural disorders are the primary drivers of disability and according to the report, it was estimated that mental behaviour and disorders were responsible for the 12% of the burden of diseases in Canada in 2003. The report also shows that the state and territory government provides health care services to people with mental illnesses by providing more facilities and healthcare providers to deal with the psychotic illnesses and mental behaviour. A report by the National Survey of Mental Health and Wellbeing show that the population treatment of people with psychotic and mental illness was about 35% where of these; 23%, 38% and 71% consulted a psychiatrist, a psychologist and a general practitioner in that order. According to the report, recent evidence shows that the low treatment rates found in 2007 have tremendously increased due to the inclusion of government subsidized mental health medications items to the Medicare benefits schedule in late 2006. Australians with mental illnesses benefit from mental health care services provided by healthcare experts in different care settings which have seen the number of psychiatric disorders decline in the country in the recent past. Specialized menta l health care is provided in different health care facilities and the services types ranges from public hospitals, residential and community or private psychiatric centres. In these facilities, the service type differs significantly with the number of beds provided for the patients. Results from the report show that in 2011 to 2012, the Australian recurrent expenditure on services related to mental health was $7.0 billion where over $4.0 billion was used on state/territory specialized mental health services. Regarding the mental health care services plus support, it was estimated that there were over sixteen million mental related GP encounters in Australia in the financial year 2012/2013. In the same year, the GP provided over 2.3 million Medicare benefits schedule mental health services to over 1.3 million Australian patients. The report finds that psychologists provided over 3.4 million Medicare benefits subsidized mental health services to almost 850, 000 patients across Australia in the year 2012/2013. Regarding the mental health-related treatment, there were almost 30 million prescriptions distributed for mental health treatments in the year 2012/2013. Statistically, 85 % of these prescriptions were provided by GP, 7% by psychiatrists and 8 % by non-psychi atrists. Regarding the expenditure, about $7.2 billion was spent on mental health-related services in the country in the year 2011/2012, where $0.851 billion went to the Medicare subsidized mental health related while $0.854 billion went to the mental health-related prescriptions. Regarding the governance and expenditure, over $4.4 billion was spent on territory and state mental health services, while $ 0.333 million on specialized mental health services private health centres. According to the report, about 13.5% of the community health care were recorded to have received an involuntary mental health care in the year 2011/2012, and they included people with schizoaffective as well as schizophrenia disorders. The report also states that clients admitted to the mental health care centres might have experienced restrictive practices like seclusion with the aim of protecting clients as well as others from imminent dangers. Finally, the report states that there were 9.6 seclusions per 1 000 bed i n public acute mental health care centres in 2012/2013. References Kreisfeld, R., Harrison, J. E., Pointer, S. C. (2014). Australian Institute of Health and Welfare. Canberra, Australia: Australian Institute of Health and Welfare.

Christianity and the Modern Music Industry free essay sample

Christians have warily accepted secular music when artists have incorporated Christian themes and imagery. A song written by Pete Seeker paraphrasing Ecclesiastic 3 Turn, Turn, Turn (1965), is a perfect example of this union. In this paper, will explore the relationship between Christianity and the modern music industry. It is not my view that the Gospel should cause all the arts to be struck down and disappear; on the contrary, I should like to see all the arts and especially music, used in the service of Him who gave and created them (Martin utter). Emergence of Rock and RollIn his book history of popular music and the emergence of rock and roll, Philip Nines begins with a metaphor depicting children playing a game of rock, paper, and scissors. Nines argues that in the realm of modern music the relations among art, commerce and politics are something like that game; each has some strong power over one another, but, at the same time, is vulnerable too third (Nines, 1992, p. 1). Nonetheless while power in the game is absolute and unidirectional; paper covers rock, rock breaks scissors, and scissors cuts paper; however, power in the music world, varies in both magnitude and direction.While asserting that in American society, art validates money, money regulates politics, and politics defines art, Nines suggests that there are exceptions to the rules and ways in which contradictory relationships can also be argued. The history of music that Nines proposes is the tale of a stormy relationship between art, commerce, and politics (Nines, 1992, p. 1). It provoked trouble right from the start in all three of these areas, and still does (Nines, 1992, p. 1). Art, commerce, and politics; these three are necessary for the understanding the development and history of music.To add a Christian element to the mix of art, commerce, and politics means to add to it equally problematic tensions that epitomize modern Christianity. This creates a whirlwind of conflict, a stormy relationship, indeed. Contemporary Christian Music Contemporary Christian music is a genre that merges two distinct musical streams; the safe, acceptable church music on one hand and rock and roll on the other. Each component continues to exist independently of contemporary Christian music, and yet their paths continue to cross as they evolve.Rock and roll continues to influence the styles found in contemporary Christian sic, which continuously alters the landscape of church music as well. Contemporary Christian music began in the late sixties and seventies with a folk-pop sound like James Taylor. The genre today is applied to most styles of contemporary popular music. Christian heavy metal, Christian rap, Christian new age, and Christian alternative rock can be found lining the shelves at your local music store under the label contemporary Christian. The name Contemporary Christian itself does not imply a certain style Of music, but labels the message that it contains.Music that contains lyrics about Jesus Christ or other Christian references are labeled Christian contemporary while music that does not is simply called secular. Does contemporary Christian music violate tradition? Contemporary Christian music has not cultivated without opposition. Critics in the church, the music industry, and even amongst the fans raised moral objections. The most frequent and basic objection came from moralists within the church. They argued that rock and roll with Christian lyrics was an abomination, and should not, in good conscience be played by Christians.The line of thought from these fundamentalist Christians follows the theory that sock and roll music is evil and that rock music drives people into sexual frenzies. These were some of the assumptions that fueled the objections of a well-known Christian leader named Jimmy Swaggers. In his book Religious rock n roll: a wolf in sheeps clothing, Swaggers states, The new so-called contemporary Christian music is incompatible with true Biblical Christianity. Emphatically state that its impossible to touch anyones heart with contemporary music. The sounds are weird, strange, and odd; correspondent to the minds of the individuals who relate to this type of music. (Swaggers, 1987, p. 35) The emphasis that Swaggers places on the music, rather than the lyrics In contemporary Christian music validates his opinion that it is the beat of the music that is evil. Swaggers, being a prominent Christian leader applies his Biblical worldview to music, not condemning music altogether. On the contrary, he is well known for his active musical ministry, recording over 50 Gospel albums, selling approximately 15 million recordings worldwide (Swaggers, 2011).He is a very gifted musician, and uses his gifts to glorify the Lord through what this paper refers to as church music. Comparing Garrets style of gospel music to anthropometry Christian music is like comparing apples to slightly different flavored apples. In his mind, however, it is enough of a difference to apply his Christian worldview, condemning it as anti-Christian. Ironically enough, if you were to look for his albums amongst the shelves of your local music store, you would find them in the contemporary Christian music section.Although he would certainly disagree that he should be placed in a special section labeled church music. Garrets statements are not completely subjective. His opinions are based in scripture, for instance, Dont copy the behavior and customs of this world, but let God transform you into a new person by changing the way you think (Romans 12:12). This verse, when applied through Garrets Christian worldview towards music, tells us that music that is of this world, or contemporary society, is not something that we should openly accommodate. This is only a partial application of the verse. If you look at the second part, it can be reasoned that God can transform your thinking about contemporary music, changing said music altogether. If changing contemporary music involves applying the transformations God has instilled, then it becomes something altogether different. It remains contemporary, but becomes about Him. Swaggers does not agree with this application of scripture to music, it does not fit within the bounds of his Christian worldview. What do the Scriptures say? When searching for the truth about contemporary Christian music we must first look at the primary source for all truth, which is Scripture.Wilkins and Sanford point out that Scripture is the foundation for any Christian worldview. They go on to state, Scripture is the first place we look and the final court of appeal in shaping a Christian worldview (Wilkins camp; Sanford, 2009, up. 210-211). While searching scripture for verses that pertain to music, it IS plain to see that God is a lover of music. Come, let us sing to the Lord! Let us shout joyfully to the Rock of our salvation (Psalms 9511). In this verse, the author associates singing and shouting; two very different sounds, but both done unto the Lord as a form of praise. Shout to the Lord, all the earth; break out in praise and sing for joy! Sing your praise to the Lord with the harp, with the harp and melodious song, with trumpets and the sound of the rams horn. Make a joyful symphony before the Lord, the King! (Psalm 98:4-6) The author on this passage sings praises accompanied by musical instruments, including the harp, trumpets, and even a rams horn. Compare the music of the harp to that of the other two. The harp is soft, soothing, quiet music. The trumpet is loud and high-pitched.The rams horn is low and throaty, emitting more of a groan than a note. These three instruments have exceptionally diverse sounds. In this text, all three are used to make a joyful symphony in praising the Lord. Praise him for his mighty works; praise his unequaled greatness! Praise him with a blast of the rams horn; praise him with the lyre and harp! Praise him with the tambourine and dancing; praise him with strings and flutes! Praise him with a clash of cymbals; praise him with loud clanging cymbals. Let everything that breathes sing praises to the Lord! Praise the Lord! Psalms 150:2-6) These verses portray a vast array of instruments being used in praising the Lord. The author praises using the rams horn, the tambourine, strings and flutes, a clash of cymbals, and loud clanging cymbals. With the addition of dancing, this Psalm sounds more like a rock concert than old seasoned church music! These scriptures describe vocal effects and instruments that are used in creating the beat of the music. And by the very nature of these instruments themselves, they gravitate toward a faster paced tempo that foreshadows modern contemporary Christian music.The Bible is packed full of these scriptures, dozens in the book of Psalms alone, all pointing to a general conclusion; God loves music! He loves a melodious choir, harmonize in perfect pitch singing gospel hymns. He doesnt mind if the Sunday morning singing is a little off-key, as long as it is making a joyful noise. Whether it be shouting unto the Lord, dancing in the isles, shaking a tambourine, blowing a horn, either made of metal, or even a real animal horn! He loves all of out attempts at giving him p raise on Sunday morning.But it doesnt stop there I will praise the Lord at all times. Will constantly speak his praises (Psalms 34: 1), he wants us to praise Him all the time, not just on Sunday morning, and not just in our church music. Is contemporary Christian music reasonable? Scripture provides truth, which is a very important factor in developing a Christian worldview. However, a Well-rounded Christian worldview needs to ring all reality under its scrutiny, our rational capacities must be employed to gather and analyze this information (Wilkins ; Sanford, 2009, p. 11). In this paper it has already been determined that contemporary Christian music is, in fact, music. It has also been proven through scriptures that God loves all music. Logic dictates that since God loves all music, and contemporary Christian music is music, then reason proves that God loves contemporary Christian music. Using that same logic, however, since God loves all music, is it necessary to use all music in praising Him? Reason says o, God is praised in the simplest shout onto Him; therefore there is no need in variety of music styles.Not in Gods eyes anyhow. We are the reason for the diversity in music. Our culture, our talent, even our age plays an important factor in how we choose to praise God. He does not require this of us, human nature with all its variables does. Thinking reasonably, since each one Of us is different, and each one Of us created with our own free will, then each one of us may choose to interact differently with our Lord. People that love the beat and rhythm of a particular kind of music will naturally be drawn o that style of music in their worship. If they really are praising God with their hearts, then God listens more to their attitude of worship more then to the beat of the drums. What does experience say? Experience is a term that requires careful definition because it involves ones personal feelings (Wilkins Sanford, 2009, p. 213). Researching this subject is nearly impossible, because it involves my personal experiences, which may or may not fit with someone elses worldview. My experience with contemporary Christian music dates back to 1991. I was fifteen years of age, and I was infatuated with rock music, specifically heavy teal rock music.This genre of music, in my young grasp of understanding, was not the kind of music you would want your parents catching you listening to. In fact, on several occasions recall my father destroying cassette tapes that he found to be objectionable. At this point in time, my worldview was not yet grounded in Christianity, so to me this secular style of music was acceptable. I cannot remember whom, but someone gave me a copy of an album containing the music of a band named Deliverance. It was the very same kind of music that loved to listen to, but the lyrics were different.The title track Weapons of our Warfare (Brown, 1990) was a paraphrase of Second Corinthians 104-5. This music was definitely contemporary, but it unashamedly described the carnality of man and the strength that can be gained by trusting in God. This music spoke to me in a revolutionary way, causing my whole worldview to change regarding music. I still listened to the music that I loved, however that music now had purpose, it wasnt just entertainment, it was teaching me the truths about Christianity. My relationship with the Lord grew because Of contemporary Christian music, and still does to this very day. Eve used contemporary Christian music as a witness tool; many conversations were sparked based on the lyrics of music was listening to in public, conversations that never would have happened had been listening to secular music. I have felt the warmth of the Holy Spirit while worshiping in church to contemporary Christian music. I know, without a doubt, that God has taken delight in praises that I have sung to Him using contemporary Christian music as a tool of worship. My worldview on modern music (Summary) Traditionally, music is a complicated mixture of art, politics, and commerce.Contemporary Christian music adds the dynamic Of a Christian undertone to this music. Contemporary Christian music is a very emotional, and sometimes controversial combination, often dividing sides between pro- and anti- contemporary Christian listeners. Scripture reinforces that God is a lover of all kinds of music, and all kinds of musical instruments. All are called to praise Him in all their undertakings, including musical expression. He does not differentiate praises because of their accompaniment musical style. If worship is sincere, then he will receive it in whatever form it is delivered.Logically speaking since all people are created differently, yet all are created with free will; plausibly all are attracted to different styles of music. Since God created mankind to be that way, He should expect those styles to manifest in the types of praise and worship that He receives. Experience shows that contemporary Christian music is not only an object to be examined though a Christian worldview; it is a tool, which can shape ones pre-existing Christian worldview. It can be a seed that helps to sprout new Christians and help believers witness to those in need of Salvation.

Social Media Book Radical Marketing

Question: Discuss about the Social Media Book for Radical Marketing? Answer: Micro environmental audit - SWOT analysis Strengths Weaknesses There is a wide gamut of products available for sale Asian and European markets have huge potentials Access to competitors operational. market and financial statements Competitors also have a wide range of products to offer Competitors also opportunities of exploiting huge potentials of the market (Hopkins and Turner, 2012) Presence of a large number of competitors and products lead to market saturation Opportunities Threats There are opportunities of forecasting future trends in terms of selling price, sales revenue and profit margins There are opportunities of modifying strategies and activities as per market forecasts (Hill and Rifkin, 1999) Competitors intentions and activities can be anticipated to a considerable extent Product designs can be modifies as per market outlooks and changing needs and requirements of customers Future market trends can be anticipated on the part of the competitors Competitors can modify objectives and strategies according to future market trends Competitors may try to get access of well established markets Product designs can be easily imitated and copied Macro environmental audit - PESTEL analysis Factors Explanation Political European and Asian countries are politically stable and encourage free trade. This in turn provides market development opportunities. Economic With the global economy recovering from recession at a considerable pace, consumers of Europe and Asia now have more disposable income in their hands. This in turn provides opportunities of increasing sales, profit margins and market share of the company (Hopkins and Turner, 2012). Interest rates vary from country to country and have direct impact on production costs and long term profit. Hence, it is an imperative to analyze interest rates at frequent intervals throughout the year so that appropriate pricing decisions can be taken. Social Social and cultural aspects of Asia and Europe are different to a great degree and have their respective influences on the purchasing behaviors of the customers. Product development and designing need to take in to consideration, these cultural differences so as to avoid degradation in perceives value. Technological Technological factors associated with Europe and Asia depicts that both Asian and European consumers are fond of high battery life and compact design. Customers of Europe prefer photo and video features and premium display features and customers of Asia prefer additional memory, security and navigation features (Hopkins and Turner, 2012). Due to prevailing cultural differences, designs need to be selected on the basis of specific preferences of customers of these two nations. Environmental Environmental considerations are important both in Europe and Asia and have become one of the parameters of judging organizational reputation. Hence, in order to increase brand value and reputation, participation in CSR activities is an imperative (Greenberg, 2010). Legal There are certain differences in the legal rules and regulations prevailing in the countries that constitute Asia and Europe in context to manufacturing and selling business. These differences in legal aspects need to be taken in to considerations and appropriate strategies are required to be developed on the basis of the differences. Critical success factors Critical success factors Explanations Pricing efficiency Competitive advantage can be successfully attained by charging high price against superior quality. Prices are charged as per demand and supply dynamics prevailing in the Asian and European market (Sovany, 2011). Cost management efficiency Efficient cost management strategies in the forms of management of cash and inventories are to be formulated and implemented irrespective of the sales and profit margin figures. Cash management initiatives include safe keeping of cash and bank reconciliations Inventory management initiatives include. Market research Market research is to involve better understandings regarding market trends on an yearly basis (Bodner and Cohen, 2012) Market research is done in such a way that marketing, advertisement, production and R D costs can be estimated in more or less accurate manners Competitive advantage Competitor advantage can be attained in an effective and efficient manner through improved customer service during and after sales. This can also be done through lengthy warranty periods, increased frequency of price reductions and innovative sales promotion and advertisement initiatives Market planning Planning elements Aims Objectives Performance indicators R D Quality improvement simultaneously with cost management through improving economics of scale Making an investment of 200000 towards research and development initiatives Market share and sales revenue figures Product Production of a range of products with specific magnitudes of quality for catering to a range of customers Making an investment of 150000 towards new product development Low to high end customer satisfaction levels (Rowles, 2008) Marketing Putting innovative marketing and promotional strategies for gaining competitive advantage (Pasqua and Elkin, 2013) Making an investment of 800000 towards marketing and promotional campaigns and social media engagement Market penetration and expansion levels Finance Concentrating expenses on sales promotion and savings on fixed costs Improvement in net profit margin from 5% to 10% within the current year Share price levels Marketing strategy Product name Product strategy Pricing strategy Positioning strategy Promotion strategy Product 1 This product was introduced in the European and Asian market as a high end product and targeted towards high end customers. All the features included in this product are of superior quality (Safko, 2010) This product was initially over priced in the European market and the same has later been brought down to good value price. In Asian market, a premium price is charged against this product due to lesser degree of market saturation Positioned as premium quality for premium customers Social media, promotional campaigns television and newspapers. Product 2 This product was first introduced as a mid range product and later converted to low end product with modifications in certain features. This product has got highest sales. The product was launched at a mid range supporting price and later price was reduced so as to keep pace with increasing demand and to cater to the needs and to cater to the needs and requirements of low end customers. Positioned as value for money for valuable customers Social media, television and newspapers. Product 3 This product was also a mid range product initially in both European and Asian markets and later converted to low end product through some feature based changes. This product contributes to second highest sale The price of this product was reduced from that of its initial launch in both with a view to satisfy low end customers (Sovany, 2011). Positioned as price less features at price less value Social media and television. Product 4 This again a premium product with premium features and price and targeted towards households of Europe and Asia. The price of the product was kept premium with no reductions. Premium prices have been maintained both in Asian and European market. Positioned as cutting edge technology for premium customers Social media, promotional campaigns television and newspapers. Product 5 This product has been featured again as a mid range product in both the markets. The price of this product has been kept slightly higher in Asia owing to the fact that market growth rate in Asia is slightly higher than in Europe Positioned as affordable by all payable by all . Social media, newspapers and television. Product 6 This product was launched as a good value product in both Asia and Europe. This product has been launched targeting the households and specifically to gain competitive advantage in the market. The price of this product has been kept to the level of mid range so that the same can provide tough competition to the rivals are the rivals are forced to reducing prices (Sovany, 2011). Positioned as love your phone, love your money. Social media, promotional campaigns and television. References Bodnar, K. and Cohen, J., 2012. The B2B social media book. Hoboken, N.J.: Wiley. Greenberg, P., 2010. CRM at the speed of light. New York: McGraw-Hill. Hill, S. and Rifkin, G., 1999. Radical marketing. New York, N.Y.: HarperBusiness. Hopkins, J. and Turner, J., 2012. Go mobile. Hoboken, N.J.: Wiley. Pasqua, R. and Elkin, N., 2013. Mobile marketing. Hoboken, N.J.: Wiley. Rowles, D., 2008. Mobile marketing. Safko, L., 2010. The social media bible. Hoboken, N.J.: Wiley. Sobhany, R., 2011. Mobilize. Philadelphia: Vanguard Press.

Scarlet Essays (520 words) - English-language Films,

Scarlet Letter By Hawthorne In this story Hester was an adulteress and had to wear a scarlet letter because she wouldn't admit to whom she had the affair with. Her daughter was Pearl and her father was Dimmesdale. They lived in Salem, Massachusetts in times of Puritans so the sin of having an affair was unacceptable. Dimmesdale was a Reverend and he wanted Hester to admit the affair, but she would not. Her husband, who was assumed dead, was Chillingworth and he figured out who the father was and he wanted revenge. He tried to drive Dimmesdale crazy, but it didn't work. Finally in the end Dimmesdale announced after his sermon that he was the father of Pearl, then he died shortly after. Pearl and Hester went back to England and Hester continued to wear the scarlet letter on her chest. I found Hester to be the most intriguing character in this story. She accepted that she had sinned and took the punishment without looking for a way out. She could have easily admitted who the father was and she wouldn't have been subject to the scorn of the townspeople, but she took it. She was punished all of her life and I do not think that she should have had to deal with that all of her life. She had to deal with her daughter who was somewhat of a brat. Finally she got some of the respect that she deserved, people came to her for advice. The conflict of the story was the act of adultery. Even today it is an issue, though some people make more a big deal about it than is needed. In the times of Puritans this was one of the worst sins that one could commit. Another conflict was that Chillingworth tried to get revenge throughout the whole story. He kept on fighting to get even with Dimmesdale, he tried to drive him crazy, but it never worked. The theme of this story is sin and who had the greater sin. They all sinned, but it is anyones opinion whose sin was worse. I think that Chillingworths was the worst, he had nothing to do with the affair, but he felt the need to get even. I think that Dimmesdale should have had to be shunned by the town just as Hester was, even though he tried to make it fair to him. I think that Hester should not have had to live with that kind of guilty conciense, it wasn't fair because she had to live with Pearl everyday. She was reminder enough of what happened and she didn't help with the situation any. In my opinion I liked the plot of the story, but I did not care for his style of writing. He wrote with very large vocabulary. He could have made it easy to understand, it doesn't even sound natural. I would like to see the movie because it would be easier to understand. I read this a while ago so not everything is very fresh in my mind, and there are parts that I did not understand. I think that it is better to come out right away with your sin, even though I wouldn't if I did that. I also think that you should not be judged based on your sins.